Cargando…
Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial
BACKGROUND: Primaquine and methylene blue are gametocytocidal compounds that could prevent Plasmodium falciparum transmission to mosquitoes. We aimed to assess the efficacy and safety of primaquine and methylene blue in preventing human to mosquito transmission of P falciparum among glucose-6-phosph...
Autores principales: | Dicko, Alassane, Roh, Michelle E, Diawara, Halimatou, Mahamar, Almahamoudou, Soumare, Harouna M, Lanke, Kjerstin, Bradley, John, Sanogo, Koualy, Kone, Daouda T, Diarra, Kalifa, Keita, Sekouba, Issiaka, Djibrilla, Traore, Sekou F, McCulloch, Charles, Stone, Will J R, Hwang, Jimee, Müller, Olaf, Brown, Joelle M, Srinivasan, Vinay, Drakeley, Chris, Gosling, Roly, Chen, Ingrid, Bousema, Teun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science ;, The Lancet Pub. Group
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968371/ https://www.ncbi.nlm.nih.gov/pubmed/29422384 http://dx.doi.org/10.1016/S1473-3099(18)30044-6 |
Ejemplares similares
-
Pyronaridine–artesunate or dihydroartemisinin–piperaquine combined with single low-dose primaquine to prevent Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a four-arm, single-blind, phase 2/3, randomised trial
por: Stone, William, et al.
Publicado: (2022) -
Transmission-blocking Effects of Primaquine and Methylene Blue Suggest Plasmodium falciparum Gametocyte Sterilization Rather Than Effects on Sex Ratio
por: Bradley, John, et al.
Publicado: (2019) -
Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians
por: Mahamar, Almahamoudou, et al.
Publicado: (2021) -
Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial
por: Chen, Ingrid, et al.
Publicado: (2018) -
Mechanistic Modeling of Primaquine Pharmacokinetics, Gametocytocidal Activity, and Mosquito Infectivity
por: Chotsiri, Palang, et al.
Publicado: (2022)