Discovery and mechanistic study of a photocatalytic indoline dehydrogenation for the synthesis of elbasvir

Elbasvir is a potent NS5A antagonist for the treatment of chronic hepatitis C. A seemingly trivial indoline oxidation en route to the target compound was complicated by epimerization of a stereogenic hemiaminal center under most standard oxidation conditions. To address this issue, a novel visible l...

Descripción completa

Detalles Bibliográficos
Autores principales: Yayla, Hatice G., Peng, Feng, Mangion, Ian K., McLaughlin, Mark, Campeau, Louis-Charles, Davies, Ian W., DiRocco, Daniel A., Knowles, Robert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968518/
https://www.ncbi.nlm.nih.gov/pubmed/29899932
http://dx.doi.org/10.1039/c5sc03350k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968518/
https://www.ncbi.nlm.nih.gov/pubmed/29899932
http://dx.doi.org/10.1039/c5sc03350k

Ejemplares similares