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Discovery and mechanistic study of a photocatalytic indoline dehydrogenation for the synthesis of elbasvir

Elbasvir is a potent NS5A antagonist for the treatment of chronic hepatitis C. A seemingly trivial indoline oxidation en route to the target compound was complicated by epimerization of a stereogenic hemiaminal center under most standard oxidation conditions. To address this issue, a novel visible l...

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Detalles Bibliográficos
Autores principales:	Yayla, Hatice G., Peng, Feng, Mangion, Ian K., McLaughlin, Mark, Campeau, Louis-Charles, Davies, Ian W., DiRocco, Daniel A., Knowles, Robert R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968518/ https://www.ncbi.nlm.nih.gov/pubmed/29899932 http://dx.doi.org/10.1039/c5sc03350k

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