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Integrating rare genetic variants into pharmacogenetic drug response predictions

BACKGROUND: Variability in genes implicated in drug pharmacokinetics or drug response can modulate treatment efficacy or predispose to adverse drug reactions. Besides common genetic polymorphisms, recent sequencing projects revealed a plethora of rare genetic variants in genes encoding proteins invo...

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Detalles Bibliográficos
Autores principales:	Ingelman-Sundberg, Magnus, Mkrtchian, Souren, Zhou, Yitian, Lauschke, Volker M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968569/ https://www.ncbi.nlm.nih.gov/pubmed/29793534 http://dx.doi.org/10.1186/s40246-018-0157-3

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