Location dependent coordination chemistry and MRI relaxivity, in de novo designed lanthanide coiled coils

Herein, we establish for the first time the design principles for lanthanide coordination within coiled coils, and the important consequences of binding site translation. By interrogating design requirements and by systematically translating binding site residues, one can influence coiled coil stabi...

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Detalles Bibliográficos
Autores principales: Berwick, Matthew R., Slope, Louise N., Smith, Caitlin F., King, Siobhan M., Newton, Sarah L., Gillis, Richard B., Adams, Gary G., Rowe, Arthur J., Harding, Stephen E., Britton, Melanie M., Peacock, Anna F. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968752/
https://www.ncbi.nlm.nih.gov/pubmed/29899946
http://dx.doi.org/10.1039/c5sc04101e

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