Radical transfer in E. coli ribonucleotide reductase: a NH(2)Y(731)/R(411)A-α mutant unmasks a new conformation of the pathway residue 731

Ribonucleotide reductases (RNRs) catalyze the conversion of ribonucleotides to deoxyribonucleotides in all living organisms. The catalytic cycle of E. coli RNR involves a long-range proton-coupled electron transfer (PCET) from a tyrosyl radical (Y(122)˙) in subunit β2 to a cysteine (C(439)) in the a...

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Detalles Bibliográficos
Autores principales: Kasanmascheff, Müge, Lee, Wankyu, Nick, Thomas U., Stubbe, JoAnne, Bennati, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968753/
https://www.ncbi.nlm.nih.gov/pubmed/29899944
http://dx.doi.org/10.1039/c5sc03460d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968753/
https://www.ncbi.nlm.nih.gov/pubmed/29899944
http://dx.doi.org/10.1039/c5sc03460d

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