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Long‐chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation

AIM: Our aim was to perform an in‐depth analysis of the composition of fatty acids in milk from mothers delivering extremely preterm babies. We investigated longitudinal changes in milk fatty acid profiles and the relationship between several types of fatty acids, including omega‐3 and omega‐6. METH...

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Autores principales: Nilsson, Anders K., Löfqvist, Chatarina, Najm, Svetlana, Hellgren, Gunnel, Sävman, Karin, Andersson, Mats X., Smith, Lois E. H., Hellström, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969106/
https://www.ncbi.nlm.nih.gov/pubmed/29444356
http://dx.doi.org/10.1111/apa.14275
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author Nilsson, Anders K.
Löfqvist, Chatarina
Najm, Svetlana
Hellgren, Gunnel
Sävman, Karin
Andersson, Mats X.
Smith, Lois E. H.
Hellström, Ann
author_facet Nilsson, Anders K.
Löfqvist, Chatarina
Najm, Svetlana
Hellgren, Gunnel
Sävman, Karin
Andersson, Mats X.
Smith, Lois E. H.
Hellström, Ann
author_sort Nilsson, Anders K.
collection PubMed
description AIM: Our aim was to perform an in‐depth analysis of the composition of fatty acids in milk from mothers delivering extremely preterm babies. We investigated longitudinal changes in milk fatty acid profiles and the relationship between several types of fatty acids, including omega‐3 and omega‐6. METHODS: Milk samples were collected at three stages of lactation from 78 mothers who delivered at less than 28 weeks of pregnancy at the Sahlgrenska University Hospital, Gothenburg, Sweden, from April 2013 to September 2015. Fatty acid composition was analysed by gas chromatography–mass spectrometry. RESULTS: A reduction in long‐chain polyunsaturated fatty acids (LCPUFAs) was observed during the lactation period. The concentrations of arachidonic acid and docosahexaenoic acid declined from medians of 0.34 to 0.22 mol% and 0.29 to 0.15 mol%, respectively, between postnatal day 7 and a postmenstrual age of 40 weeks. Strong correlations were found between the intermediates of several classes of fatty acids, including omega‐3, omega‐6 and omega‐9. CONCLUSION: A rapid reduction in LCPUFA content in the mother's milk during the lactation period emphasises the importance of fatty acid supplementation to infants born extremely preterm, at least during the period corresponding to the third trimester, when rapid development of the brain and adipose tissue requires high levels of LCPUFAs.
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spelling pubmed-59691062018-05-30 Long‐chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation Nilsson, Anders K. Löfqvist, Chatarina Najm, Svetlana Hellgren, Gunnel Sävman, Karin Andersson, Mats X. Smith, Lois E. H. Hellström, Ann Acta Paediatr Regular Articles AIM: Our aim was to perform an in‐depth analysis of the composition of fatty acids in milk from mothers delivering extremely preterm babies. We investigated longitudinal changes in milk fatty acid profiles and the relationship between several types of fatty acids, including omega‐3 and omega‐6. METHODS: Milk samples were collected at three stages of lactation from 78 mothers who delivered at less than 28 weeks of pregnancy at the Sahlgrenska University Hospital, Gothenburg, Sweden, from April 2013 to September 2015. Fatty acid composition was analysed by gas chromatography–mass spectrometry. RESULTS: A reduction in long‐chain polyunsaturated fatty acids (LCPUFAs) was observed during the lactation period. The concentrations of arachidonic acid and docosahexaenoic acid declined from medians of 0.34 to 0.22 mol% and 0.29 to 0.15 mol%, respectively, between postnatal day 7 and a postmenstrual age of 40 weeks. Strong correlations were found between the intermediates of several classes of fatty acids, including omega‐3, omega‐6 and omega‐9. CONCLUSION: A rapid reduction in LCPUFA content in the mother's milk during the lactation period emphasises the importance of fatty acid supplementation to infants born extremely preterm, at least during the period corresponding to the third trimester, when rapid development of the brain and adipose tissue requires high levels of LCPUFAs. John Wiley and Sons Inc. 2018-03-13 2018-06 /pmc/articles/PMC5969106/ /pubmed/29444356 http://dx.doi.org/10.1111/apa.14275 Text en ©2018 The Authors. Acta Pædiatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Pædiatrica This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Regular Articles
Nilsson, Anders K.
Löfqvist, Chatarina
Najm, Svetlana
Hellgren, Gunnel
Sävman, Karin
Andersson, Mats X.
Smith, Lois E. H.
Hellström, Ann
Long‐chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation
title Long‐chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation
title_full Long‐chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation
title_fullStr Long‐chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation
title_full_unstemmed Long‐chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation
title_short Long‐chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation
title_sort long‐chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969106/
https://www.ncbi.nlm.nih.gov/pubmed/29444356
http://dx.doi.org/10.1111/apa.14275
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