Advanced glycation end‐products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

Insufficient autophagy in podocytes is related to podocyte injury in diabetic nephropathy (DN). Advanced glycation end‐products (AGEs) are major factors of podocyte injury in DN. However, the role and mechanism of AGEs in autophagic dysfunction remain unknown. We investigated autophagic flux in AGE‐...

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Detalles Bibliográficos
Autores principales: Zhao, Xingchen, Chen, Yuanhan, Tan, Xiaofan, Zhang, Li, Zhang, Hong, Li, Zhilian, Liu, Shuangxin, Li, Ruizhao, Lin, Ting, Liao, Ruyi, Zhang, Qianmei, Dong, Wei, Shi, Wei, Liang, Xinling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2018
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969319/
https://www.ncbi.nlm.nih.gov/pubmed/29570219
http://dx.doi.org/10.1002/path.5077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969319/
https://www.ncbi.nlm.nih.gov/pubmed/29570219
http://dx.doi.org/10.1002/path.5077

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