Targeting both tumour-associated CXCR2(+) neutrophils and CCR2(+) macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

OBJECTIVE: Chemokine pathways are co-opted by pancreatic adenocarcinoma (PDAC) to facilitate myeloid cell recruitment from the bone marrow to establish an immunosuppressive tumour microenvironment (TME). Targeting tumour-associated CXCR2(+)neutrophils (TAN) or tumour-associated CCR2(+) macrophages (...

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Detalles Bibliográficos
Autores principales: Nywening, Timothy M, Belt, Brian A, Cullinan, Darren R, Panni, Roheena Z, Han, Booyeon J, Sanford, Dominic E, Jacobs, Ryan C, Ye, Jian, Patel, Ankit A, Gillanders, William E, Fields, Ryan C, DeNardo, David G, Hawkins, William G, Goedegebuure, Peter, Linehan, David C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Pancreas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969359/
https://www.ncbi.nlm.nih.gov/pubmed/29196437
http://dx.doi.org/10.1136/gutjnl-2017-313738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969359/
https://www.ncbi.nlm.nih.gov/pubmed/29196437
http://dx.doi.org/10.1136/gutjnl-2017-313738

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