Asymmetric synthesis of multiple quaternary stereocentre-containing cyclopentyls by oxazolidinone-promoted Nazarov cyclizations

Carbometalation of oxazolidinone (Ox)-substituted ynamides is used to generate highly substituted Ox-divinyl (and aryl vinyl) ketones for use in Nazarov cyclizations. The Ox-group serves as a remarkably effective chiral activating group, enabling the torquoselective Nazarov cyclization of these ster...

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Detalles Bibliográficos
Autores principales: Volpe, Rohan, Lepage, Romain J., White, Jonathan M., Krenske, Elizabeth H., Flynn, Bernard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969496/
https://www.ncbi.nlm.nih.gov/pubmed/29899958
http://dx.doi.org/10.1039/c8sc00031j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969496/
https://www.ncbi.nlm.nih.gov/pubmed/29899958
http://dx.doi.org/10.1039/c8sc00031j

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