The Rbm38-p63 Feedback Loop Is Critical for Tumor Suppression and Longevity

The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop. To investigate the biological significance of the Rbm38-p63 loop in vivo, a cohort of WT, Rbm38(−/−), TAp63(+/−) and Rbm38(−...

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Detalles Bibliográficos
Autores principales: Jiang, Yuqian, Xu, Enshun, Zhang, Jin, Chen, Mingyi, Flores, Elsa, Chen, Xinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970038/
https://www.ncbi.nlm.nih.gov/pubmed/29520104
http://dx.doi.org/10.1038/s41388-018-0176-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970038/
https://www.ncbi.nlm.nih.gov/pubmed/29520104
http://dx.doi.org/10.1038/s41388-018-0176-5

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