Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines

Lomaiviticin A and difluostatin A are benzofluorene-containing aromatic polyketides in the atypical angucycline family. Although these dimeric compounds are potent antitumor agents, how nature constructs their complex structures remains poorly understood. Herein, we report the discovery of a number...

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Detalles Bibliográficos
Autores principales: Huang, Chunshuai, Yang, Chunfang, Zhang, Wenjun, Zhang, Liping, De, Bidhan Chandra, Zhu, Yiguang, Jiang, Xiaodong, Fang, Chunyan, Zhang, Qingbo, Yuan, Cheng-Shan, Liu, Hung-wen, Zhang, Changsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970136/
https://www.ncbi.nlm.nih.gov/pubmed/29802272
http://dx.doi.org/10.1038/s41467-018-04487-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970136/
https://www.ncbi.nlm.nih.gov/pubmed/29802272
http://dx.doi.org/10.1038/s41467-018-04487-z

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