Non-blocking modulation contributes to sodium channel inhibition by a covalently attached photoreactive riluzole analog

Sodium channel inhibitor drugs decrease pathological hyperactivity in various diseases including pain syndromes, myotonia, arrhythmias, nerve injuries and epilepsies. Inhibiting pathological but not physiological activity, however, is a major challenge in drug development. Sodium channel inhibitors...

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Detalles Bibliográficos
Autores principales: Lukacs, Peter, Földi, Mátyás C., Valánszki, Luca, Casanova, Emilio, Biri-Kovács, Beáta, Nyitray, László, Málnási-Csizmadia, András, Mike, Arpad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970139/
https://www.ncbi.nlm.nih.gov/pubmed/29802266
http://dx.doi.org/10.1038/s41598-018-26444-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970139/
https://www.ncbi.nlm.nih.gov/pubmed/29802266
http://dx.doi.org/10.1038/s41598-018-26444-y

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