Cargando…

Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice

PMX53 and PMX205 are cyclic hexapeptide inhibitors of complement C5a receptors (C5aR1), that are widely used to study C5aR1 pathobiology in mouse models of disease. Despite their widespread use, limited information regarding their pharmacokinetics have been reported. Here, a bioanalytical method for...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Vinod, Lee, John D., Clark, Richard J., Woodruff, Trent M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970165/
https://www.ncbi.nlm.nih.gov/pubmed/29802264
http://dx.doi.org/10.1038/s41598-018-26387-4