Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor

Structural studies of integral membrane proteins have been limited by the intrinsic conformational flexibility and the need to stabilize the proteins in solution. Stabilization by mutagenesis was very successful for structural biology of G protein-coupled receptors (GPCRs). However, it requires heav...

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Detalles Bibliográficos
Autores principales: Igonet, Sébastien, Raingeval, Claire, Cecon, Erika, Pučić-Baković, Maja, Lauc, Gordan, Cala, Olivier, Baranowski, Maciej, Perez, Javier, Jockers, Ralf, Krimm, Isabelle, Jawhari, Anass
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970182/
https://www.ncbi.nlm.nih.gov/pubmed/29802269
http://dx.doi.org/10.1038/s41598-018-26113-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970182/
https://www.ncbi.nlm.nih.gov/pubmed/29802269
http://dx.doi.org/10.1038/s41598-018-26113-0

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