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The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function

The Ccr4-Not complex controls RNA polymerase II (Pol II) dependent gene expression and proteasome function. The Not4 ubiquitin ligase is a Ccr4-Not subunit that has both a RING domain and a conserved RNA recognition motif and C3H1 domain (referred to as the RRM-C domain) with unknown function. We de...

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Detalles Bibliográficos
Autores principales: Chen, Hongfeng, Sirupangi, Tirupataiah, Wu, Zhao-Hui, Johnson, Daniel L., Laribee, R. Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970261/
https://www.ncbi.nlm.nih.gov/pubmed/29802328
http://dx.doi.org/10.1038/s41598-018-26576-1