Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep

BACKGROUND: The simplicity of the CRISPR/Cas9 system has enabled its widespread applications in generating animal models, functional genomic screening and in treating genetic and infectious diseases. However, unintended mutations produced by off-target CRISPR/Cas9 nuclease activity may lead to negat...

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Detalles Bibliográficos
Autores principales: Wang, Xiaolong, Liu, Jing, Niu, Yiyuan, Li, Yan, Zhou, Shiwei, Li, Chao, Ma, Baohua, Kou, Qifang, Petersen, Bjoern, Sonstegard, Tad, Huang, Xingxu, Jiang, Yu, Chen, Yulin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970491/
https://www.ncbi.nlm.nih.gov/pubmed/29801435
http://dx.doi.org/10.1186/s12864-018-4712-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970491/
https://www.ncbi.nlm.nih.gov/pubmed/29801435
http://dx.doi.org/10.1186/s12864-018-4712-z

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