Cargando…

Skeletal muscle mitochondrial oxidative phosphorylation function in idiopathic pulmonary arterial hypertension: in vivo and in vitro study

Mitochondrial dysfunction within the pulmonary vessels has been shown to contribute to the pathology of idiopathic pulmonary arterial hypertension (IPAH). We investigated the hypothesis of whether impaired exercise capacity observed in IPAH patients is in part due to primary mitochondrial oxidative...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sithamparanathan, Sasiharan, Rocha, Mariana C., Parikh, Jehill D., Rygiel, Karolina A., Falkous, Gavin, Grady, John P., Hollingsworth, Kieren G., Trenell, Michael I., Taylor, Robert W., Turnbull, Doug M., Gorman, Gráinne S., Corris, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2018
Materias:	Research Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971390/ https://www.ncbi.nlm.nih.gov/pubmed/29799315 http://dx.doi.org/10.1177/2045894018768290

Ejemplares similares

High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial
por: Cassidy, Sophie, et al.
Publicado: (2015)

A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis
por: Rocha, Mariana C., et al.
Publicado: (2015)

Respiratory chain deficiency in aged spinal motor neurons()
por: Rygiel, Karolina A., et al.
Publicado: (2014)

Mitochondrial and inflammatory changes in sporadic inclusion body myositis
por: Rygiel, Karolina A., et al.
Publicado: (2015)

Subcellular origin of mitochondrial DNA deletions in human skeletal muscle
por: Vincent, Amy E., et al.
Publicado: (2018)

Measurement of pulse wave velocity in normal ageing: comparison of Vicorder and magnetic resonance phase contrast imaging
por: Parikh, Jehill D., et al.
Publicado: (2016)

Cardiomyopathy is common in patients with the mitochondrial DNA m.3243A>G mutation and correlates with mutation load
por: Hollingsworth, Kieren G., et al.
Publicado: (2012)

Normal age-related changes in left ventricular function: Role of afterload and subendocardial dysfunction
por: Parikh, Jehill D., et al.
Publicado: (2016)

Left ventricular functional, structural and energetic effects of normal aging: Comparison with hypertension
por: Parikh, Jehill D., et al.
Publicado: (2017)

Disease progression in patients with single, large-scale mitochondrial DNA deletions
por: Grady, John P., et al.
Publicado: (2014)

Mitochondrial dysfunction in myofibrillar myopathy
por: Vincent, Amy E., et al.
Publicado: (2016)

The ageing neuromuscular system and sarcopenia: a mitochondrial perspective
por: Rygiel, Karolina A., et al.
Publicado: (2016)

Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression
por: Gorman, Grainne S., et al.
Publicado: (2015)

Distal weakness with respiratory insufficiency caused by the m.8344A > G “MERRF” mutation
por: Blakely, Emma L., et al.
Publicado: (2014)

Triplex real-time PCR–an improved method to detect a wide spectrum of mitochondrial DNA deletions in single cells
por: Rygiel, Karolina A., et al.
Publicado: (2015)

Dysferlin mutations and mitochondrial dysfunction
por: Vincent, Amy E., et al.
Publicado: (2016)

Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers(†)
por: Bates, Matthew G.D., et al.
Publicado: (2013)

Variations in right atrial flow patterns in the normal heart a potential contributor to cryptogenic stroke in the setting of patent foramen ovale
por: Parikh, Jehill D, et al.
Publicado: (2015)

4D flow MRI assessment of right atrial flow patterns in the normal heart – influence of caval vein arrangement and implications for the patent foramen ovale
por: Parikh, Jehill D., et al.
Publicado: (2017)

Increased Daily Walking Improves Lipid Oxidation Without Changes in Mitochondrial Function in Type 2 Diabetes
por: Trenell, Michael I., et al.
Publicado: (2008)

The Rheumatoid Arthritis and MUScle (RAMUS) Study: Protocol for an observational single-arm study of skeletal muscle in patients with rheumatoid arthritis receiving tofacitinib
por: Bennett, Joshua L., et al.
Publicado: (2023)

Impact of age on the association between cardiac high-energy phosphate metabolism and cardiac power in women
por: Nathania, Maria, et al.
Publicado: (2018)

The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy
por: Vincent, Amy E., et al.
Publicado: (2016)

Habitual Physical Activity in Mitochondrial Disease
por: Apabhai, Shehnaz, et al.
Publicado: (2011)

Pathogenic mtDNA mutations causing mitochondrial myopathy: The need for muscle biopsy
por: Hardy, Steven A., et al.
Publicado: (2016)

Denervation Causes Fiber Atrophy and Myosin Heavy Chain Co-Expression in Senescent Skeletal Muscle
por: Rowan, Sharon L., et al.
Publicado: (2012)

Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue
por: Grünewald, Anne, et al.
Publicado: (2014)

Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network
por: Vincent, Amy E., et al.
Publicado: (2019)

Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network
por: Vincent, Amy E., et al.
Publicado: (2019)

Naked mole-rats maintain healthy skeletal muscle and Complex IV mitochondrial enzyme function into old age
por: Stoll, Elizabeth A, et al.
Publicado: (2016)

Using a quantitative quadruple immunofluorescent assay to diagnose isolated mitochondrial Complex I deficiency
por: Ahmed, Syeda T., et al.
Publicado: (2017)

Mitochondrial DNA Depletion in Respiratory Chain–Deficient Parkinson Disease Neurons
por: Grünewald, Anne, et al.
Publicado: (2016)

OPA1 mutations impair mitochondrial function in both pure and complicated dominant optic atrophy
por: Yu-Wai-Man, Patrick, et al.
Publicado: (2011)

Sudden adult death syndrome in m.3243A>G-related mitochondrial disease: an unrecognized clinical entity in young, asymptomatic adults
por: Ng, Yi Shiau, et al.
Publicado: (2016)

Complex mitochondrial DNA rearrangements in individual cells from patients with sporadic inclusion body myositis
por: Rygiel, Karolina A., et al.
Publicado: (2016)

Scientific and Ethical Issues in Mitochondrial Donation
por: Craven, Lyndsey, et al.
Publicado: (2018)

Extensive respiratory chain defects in inhibitory interneurones in patients with mitochondrial disease
por: Lax, Nichola Z., et al.
Publicado: (2015)

Adult‐onset myoclonus ataxia associated with the mitochondrial m.8993T>C “NARP” mutation
por: Martikainen, Mika H., et al.
Publicado: (2015)

Mitochondrial respiratory chain function and content are preserved in the skeletal muscle of active very old men and women
por: Dodds, R.M., et al.
Publicado: (2018)

Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
por: Hallsworth, Kate, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_rbnnide4nmakrfuqlsqpkgq562