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Small molecules that inhibit the late stage of Munc13-4–dependent secretory granule exocytosis in mast cells

Ca(2+)-dependent secretory granule fusion with the plasma membrane is the final step for the exocytic release of inflammatory mediators, neuropeptides, and peptide hormones. Secretory cells use a similar protein machinery at late steps in the regulated secretory pathway, employing protein isoforms f...

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Detalles Bibliográficos
Autores principales:	Bruinsma, Stephen, James, Declan J., Quintana Serrano, Melanie, Esquibel, Joseph, Woo, Sang Su, Kielar-Grevstad, Elle, Crummy, Ellen, Qurashi, Rehan, Kowalchyk, Judy A., Martin, Thomas F. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971468/ https://www.ncbi.nlm.nih.gov/pubmed/29615494 http://dx.doi.org/10.1074/jbc.RA117.001547

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