Cargando…

Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis

An abnormality in the Lin28/let-7a axis is relevant to the progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor. The present study aimed to investigate the antiproliferative and anti-invasive effects of uro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qiu, Zhenpeng, Zhou, Junxuan, Zhang, Cong, Cheng, Ye, Hu, Junjie, Zheng, Guohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Associação Brasileira de Divulgação Científica 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972012/ https://www.ncbi.nlm.nih.gov/pubmed/29742265 http://dx.doi.org/10.1590/1414-431X20187220

Ejemplares similares

HBV Integration-mediated Cell Apoptosis in HepG2.2.15
por: Hu, Xiaoge, et al.
Publicado: (2019)

Dihydroartemisinin inhibits HepG2.2.15 proliferation by inducing cellular senescence and autophagy
por: Zou, Jiang, et al.
Publicado: (2019)

TMEM2 inhibits hepatitis B virus infection in HepG2 and HepG2.2.15 cells by activating the JAK–STAT signaling pathway
por: Zhu, X, et al.
Publicado: (2016)

An earthworm protease cleaving serum fibronectin and decreasing HBeAg in HepG2.2.15 cells
por: Wang, Xue-Qing, et al.
Publicado: (2008)

MicroRNA-520a suppresses HBV replication in HepG2.2.15 cells by inactivating AKT
por: Sun, Wei, et al.
Publicado: (2018)

Two fragments of HBV DNA integrated into chrX: 11009033 and its genetic regulation in HepG2.2.15
por: Ruan, Peng, et al.
Publicado: (2023)

Ellagic Acid-Derived Urolithins as Modulators of Oxidative Stress
por: Djedjibegovic, Jasmina, et al.
Publicado: (2020)

IFN-CSP Inhibiting Hepatitis B Virus in HepG2.2.15 Cells Involves JAK-STAT Signal Pathway
por: Lu, Xuemei, et al.
Publicado: (2015)

Anti-Hepatitis B Virus Activity of Chickweed [Stellaria media (L.) Vill.] Extracts in HepG2.2.15 Cells
por: Ma, Lihua, et al.
Publicado: (2012)

Global analysis of HBV-mediated host proteome and ubiquitylome change in HepG2.2.15 human hepatoblastoma cell line
por: Yuan, Sen, et al.
Publicado: (2021)

The LIN28/let-7 Pathway in Cancer
por: Balzeau, Julien, et al.
Publicado: (2017)

Preparation of β-CD-Ellagic Acid Microspheres and Their Effects on HepG2 Cell Proliferation
por: Wang, Hongkai, et al.
Publicado: (2017)

Hepatitis B virus induces G1 phase arrest by regulating cell cycle genes in HepG2.2.15 cells
por: Wang, Tianzhen, et al.
Publicado: (2011)

Oxidative Stress, Antioxidant Capabilities, and Bioavailability: Ellagic Acid or Urolithins?
por: Alfei, Silvana, et al.
Publicado: (2020)

Effect of modified Xiaochaihu decoction-containing serum on HepG2.2.15 cells via the JAK2/STAT3 signaling pathway
por: Chen, Shaofang, et al.
Publicado: (2017)

Trametenolic Acid B Triggers HSP90AA4P and Autophagy in HepG2/2.2.15 Cells by Proteomic Analysis
por: Shi, Feifan, et al.
Publicado: (2020)

Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection
por: Kujawska, Małgorzata, et al.
Publicado: (2020)

Suppression of USP18 Potentiates the Anti-HBV Activity of Interferon Alpha in HepG2.2.15 Cells via JAK/STAT Signaling
por: Li, Lin, et al.
Publicado: (2016)

Identification of targets of JS-K against HBV-positive human hepatocellular carcinoma HepG2.2.15 cells with iTRAQ proteomics
por: Liu, Zhengyun, et al.
Publicado: (2021)

The effect of desacetyluvaricin on the expression of TLR4 and P53 protein in Hepg 2.2.15
por: He, Hai Bin, et al.
Publicado: (2011)

Correction: Suppression of USP18 Potentiates the Anti-HBV Activity of Interferon Alpha in HepG2.2.15 Cells via JAK/STAT Signaling
por: Li, Lin, et al.
Publicado: (2016)

Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far
por: Espín, Juan Carlos, et al.
Publicado: (2013)

Antitumor effect and mechanism of an ellagic acid derivative on the HepG2 human hepatocellular carcinoma cell line
por: ZHANG, HUI, et al.
Publicado: (2014)

Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells
por: Dai, Zhi-Jun, et al.
Publicado: (2013)

Antiproliferative and Apoptotic Effects of Cardamonin against Hepatocellular Carcinoma HepG2 Cells
por: Badroon, Nassrin A., et al.
Publicado: (2020)

Emblic Leafflower (Phyllanthus emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A
por: Zhou, Junxuan, et al.
Publicado: (2018)

ADAR1 Inhibits HBV DNA Replication via Regulating miR-122-5p in Palmitic Acid Treated HepG2.2.15 Cells
por: Yang, Hongli, et al.
Publicado: (2022)

Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
por: Yermalovich, Alena V., et al.
Publicado: (2019)

Gut Bacteria Involved in Ellagic Acid Metabolism To Yield Human Urolithin Metabotypes Revealed
por: Iglesias-Aguirre, Carlos E., et al.
Publicado: (2023)

Mechanism of Dis3L2 substrate recognition in the Lin28/let-7 pathway
por: Faehnle, Christopher R., et al.
Publicado: (2014)

Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells
por: Frasson, Lorena Teixeira, et al.
Publicado: (2021)

Genome-Wide Transcriptome Analysis of CD36 Overexpression in HepG2.2.15 Cells to Explore Its Regulatory Role in Metabolism and the Hepatitis B Virus Life Cycle
por: Huang, Jian, et al.
Publicado: (2016)

TDV-2215
Publicado: (1980)

Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer
por: Wang, Tianzhen, et al.
Publicado: (2015)

The Lin28/let-7 axis is critical for myelination in the peripheral nervous system
por: Gökbuget, Deniz, et al.
Publicado: (2015)

LIN28B and Let-7 in Diffuse Midline Glioma: A Review
por: Knowles, Truman, et al.
Publicado: (2023)

Effect of yellowing time on bioactive compounds in yellow tea and their antiproliferative capacity in HepG2 cells
por: An, Ran, et al.
Publicado: (2019)

Antiproliferative Effects of Ferulic, Coumaric, and Caffeic Acids in HepG2 Cells by hTERT Downregulation
por: Afshari, Afsoon, et al.
Publicado: (2022)

Preparation and Characterization of an Oyster Peptide–Zinc Complex and Its Antiproliferative Activity on HepG(2) Cells
por: Peng, Bo, et al.
Publicado: (2023)

Developmental regulation of myeloerythroid progenitor function by the Lin28b–let-7–Hmga2 axis
por: Rowe, R. Grant, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5gddcrujkdn5030778j9kj9gkj