Cargando…

Hypoxia-induced hyperpermeability of rat glomerular endothelial cells involves HIF-2α mediated changes in the expression of occludin and ZO-1

This study aimed to investigate the role of hypoxia-inducible factor-2α (HIF-2α) in the expression of tight junction proteins and permeability alterations in rat glomerular endothelial cells (rGENCs) under hypoxia conditions. The expression level of HIF-2α and tight junction proteins (occludin and Z...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Peng-Li, Wang, Yan-Jun, Yang, Yan-Yan, Yang, Jia-Jia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Associação Brasileira de Divulgação Científica 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972023/ https://www.ncbi.nlm.nih.gov/pubmed/29791586 http://dx.doi.org/10.1590/1414-431X20186201

Ejemplares similares

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
Publicado: (1994)

Scutellarin-treated exosomes increase claudin 5, occludin and ZO1 expression in rat brain microvascular endothelial cells
por: Zhong, Xiaoqin, et al.
Publicado: (2019)

Connexin-Occludin Chimeras Containing the Zo-Binding Domain of Occludin Localize at Mdck Tight Junctions and Nrk Cell Contacts
por: Mitic, Laura L., et al.
Publicado: (1999)

Hyperoxia disrupts pulmonary epithelial barrier in newborn rats via the deterioration of occludin and ZO-1
por: You, Kai, et al.
Publicado: (2012)

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin
por: Haskins, Julie, et al.
Publicado: (1998)

A complex affair: Attraction and repulsion make occludin and ZO-1 function!
por: Bewley, Maria C., et al.
Publicado: (2013)

Roles of claudin-2, ZO-1 and occludin in leaky HK-2 cells
por: Kim, Sua, et al.
Publicado: (2017)

Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature
por: Jiang, Youde, et al.
Publicado: (2017)

Curcumin Improved Intestinal Epithelial Barrier Integrity by Up-Regulating ZO-1/Occludin/Claudin-1 in Septic Rats
por: Liu, Xiaofeng, et al.
Publicado: (2022)

β-Conglycinin Reduces the Tight Junction Occludin and ZO-1 Expression in IPEC-J2
por: Zhao, Yuan, et al.
Publicado: (2014)

CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity
por: Dörfel, Max J, et al.
Publicado: (2013)

Recombinant Human Sonic Hedgehog Protein Regulates the Expression of ZO-1 and Occludin by Activating Angiopoietin-1 in Stroke Damage
por: Xia, Yuan-peng, et al.
Publicado: (2013)

Cadmium regulates von Willebrand factor and occludin expression in glomerular endothelial cells of mice in a TNF-α-dependent manner
por: Sun, Zongguo, et al.
Publicado: (2019)

Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development
por: Xu, Xuewen, et al.
Publicado: (2020)

Mechanisms of Mechanical Force Induced Pulmonary Vascular Endothelial Hyperpermeability
por: Lai, Yan, et al.
Publicado: (2021)

Overexpression of netrin-1 increases the expression of tight junction-associated proteins, claudin-5, occludin, and ZO-1, following traumatic brain injury in rats
por: WEN, JIANFENG, et al.
Publicado: (2014)

Simvastatin Alleviates Hyperpermeability of Glomerular Endothelial Cells in Early-Stage Diabetic Nephropathy by Inhibition of RhoA/ROCK1
por: Peng, Hui, et al.
Publicado: (2013)

Dietary Aronia melanocarpa Pomace Supplementation Enhances the Expression of ZO-1 and Occludin and Promotes Intestinal Development in Pigs
por: Ren, Zhongshuai, et al.
Publicado: (2022)

Caveolin-1 Regulates Rac1 Activation and Rat Pulmonary Microvascular Endothelial Hyperpermeability Induced by TNF-α
por: Shao, Min, et al.
Publicado: (2013)

Comparison of the Modulating Effect of Anthocyanin-Rich Sour Cherry Extract on Occludin and ZO-1 on Caco-2 and HUVEC Cultures
por: Remenyik, Judit, et al.
Publicado: (2022)

Mechanism of hif-1α mediated hypoxia-induced permeability changes in bladder endothelial cells
por: Liu, C., et al.
Publicado: (2017)

CXCL13 Is Involved in the Lipopolysaccharide-Induced Hyperpermeability of Umbilical Vein Endothelial Cells
por: Chen, Wen, et al.
Publicado: (2020)

Endothelial mechanisms for inactivation of inflammation-induced hyperpermeability
por: Nepali, Prerna R., et al.
Publicado: (2023)

Occludin Promotes Adhesion of CD8(+) T Cells and Melanocytes in Vitiligo via the HIF-1α Signaling Pathway
por: Zou, Puyu, et al.
Publicado: (2022)

HIF-1α contributes to hypoxia adaptation of the naked mole rat
por: Xiao, Bang, et al.
Publicado: (2017)

TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK
por: Ni, Yawen, et al.
Publicado: (2017)

Activation of mTOR mediates hyperglycemia-induced renal glomerular endothelial hyperpermeability via the RhoA/ROCK/pMLC signaling pathway
por: Chen, Xiaolin, et al.
Publicado: (2021)

Clemizole and La(3+) salts ameliorate angiotensin II‐induced glomerular hyperpermeability in vivo
por: Dolinina, Julia, et al.
Publicado: (2021)

MiR-429 Regulated by Endothelial Monocyte Activating Polypeptide-II (EMAP-II) Influences Blood-Tumor Barrier Permeability by Inhibiting the Expressions of ZO-1, Occludin and Claudin-5
por: Chen, Liangyu, et al.
Publicado: (2018)

Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at TYR705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells
por: Wang, Yan, et al.
Publicado: (2015)

Anagliptin Protected against Hypoxia/Reperfusion-Induced Brain Vascular Endothelial Permeability by Increasing ZO-1
por: Li, Chuo, et al.
Publicado: (2021)

TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression
por: Gao, Hanchao, et al.
Publicado: (2019)

Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability
por: Li, Yicong, et al.
Publicado: (2016)

Effect of Lipoxin A(4) on Lipopolysaccharide-Induced Endothelial Hyperpermeability
por: Pang, Huayan, et al.
Publicado: (2011)

Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation
por: Sakakibara, Akira, et al.
Publicado: (1997)

The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium
Publicado: (1990)

HIF-1α-Mediated, NADPH Oxidase-Derived ROS Contributes to Laryngeal Airway Hyperreactivity Induced by Intermittent Hypoxia in Rats
por: Lin, You Shuei, et al.
Publicado: (2020)

Hydroxysafflor Yellow A Blocks HIF-1α Induction of NOX2 and Protects ZO-1 Protein in Cerebral Microvascular Endothelium
por: Li, Yi, et al.
Publicado: (2022)

R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing
por: Rouaud, Florian, et al.
Publicado: (2019)

Different Contributions of Clathrin- and Caveolae-Mediated Endocytosis of Vascular Endothelial Cadherin to Lipopolysaccharide-Induced Vascular Hyperpermeability
por: Zhang, Ye, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_48s910crenuigurfo3u78h6h8d