Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer’s Disease Disrupt Synaptic Plasticity

The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes of human iPSC-derived neuronal models of Alzheimer’s disease. When introduced i...

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Detalles Bibliográficos
Autores principales: Hu, Neng-Wei, Corbett, Grant T., Moore, Steven, Klyubin, Igor, O’Malley, Tiernan T., Walsh, Dominic M., Livesey, Frederick J., Rowan, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972225/
https://www.ncbi.nlm.nih.gov/pubmed/29768194
http://dx.doi.org/10.1016/j.celrep.2018.04.040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972225/
https://www.ncbi.nlm.nih.gov/pubmed/29768194
http://dx.doi.org/10.1016/j.celrep.2018.04.040

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