The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts

Mammalian genomes are promiscuously transcribed, yielding protein-coding and non-coding products. Many transcripts are short lived due to their nuclear degradation by the ribonucleolytic RNA exosome. Here, we show that abolished nuclear exosome function causes the formation of distinct nuclear foci,...

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Detalles Bibliográficos
Autores principales: Silla, Toomas, Karadoulama, Evdoxia, Mąkosa, Dawid, Lubas, Michal, Jensen, Torben Heick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972229/
https://www.ncbi.nlm.nih.gov/pubmed/29768216
http://dx.doi.org/10.1016/j.celrep.2018.04.061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972229/
https://www.ncbi.nlm.nih.gov/pubmed/29768216
http://dx.doi.org/10.1016/j.celrep.2018.04.061

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