Autoimmune-Mediated Thymic Atrophy Is Accelerated but Reversible in RelB-Deficient Mice

Polymorphisms impacting thymic function may decrease peripheral tolerance and hasten autoimmune disease. The NF-κB transcription factor subunit, RelB, is essential for the development and differentiation of medullary thymic epithelial cells (mTECs): RelB-deficient mice have reduced thymic cellularit...

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Detalles Bibliográficos
Autores principales: O’Sullivan, Brendan J., Yekollu, Suman, Ruscher, Roland, Mehdi, Ahmed M., Maradana, Muralidhara Rao, Chidgey, Ann P., Thomas, Ranjeny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972300/
https://www.ncbi.nlm.nih.gov/pubmed/29872433
http://dx.doi.org/10.3389/fimmu.2018.01092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972300/
https://www.ncbi.nlm.nih.gov/pubmed/29872433
http://dx.doi.org/10.3389/fimmu.2018.01092

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