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T Cell Receptor Alpha Chain Genes in the Teleost Ballan Wrasse (Labrus bergylta) Are Subjected to Somatic Hypermutation

Previously, somatic hypermutation (SHM) was considered to be exclusively associated with affinity maturation of antibodies, although it also occurred in T cells under certain conditions. More recently, it has been shown that SHM generates diversity in the variable domain of T cell receptor (TCR) in...

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Detalles Bibliográficos
Autores principales: Bilal, Sumaira, Lie, Kai Kristoffer, Sæle, Øystein, Hordvik, Ivar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972329/
https://www.ncbi.nlm.nih.gov/pubmed/29872436
http://dx.doi.org/10.3389/fimmu.2018.01101