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Bidirectional variation in glutamate efflux in the medial prefrontal cortex induced by selective positive and negative allosteric mGluR5 modulators

Dysregulation of prefrontal cortical glutamatergic signalling via NMDA receptor hypofunction has been implicated in cognitive dysfunction and impaired inhibitory control in such neuropsychiatric disorders as schizophrenia, attention‐deficit hyperactivity disorder and drug addiction. Although NMDA re...

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Detalles Bibliográficos
Autores principales: Isherwood, Sarah N., Robbins, Trevor W., Dalley, Jeffrey W., Pekcec, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972455/
https://www.ncbi.nlm.nih.gov/pubmed/29315577
http://dx.doi.org/10.1111/jnc.14290