Bidirectional GPR119 Agonism Requires Peptide YY and Glucose for Activity in Mouse and Human Colon Mucosa

The lipid sensor G protein–coupled receptor 119 (GPR119) is highly expressed by enteroendocrine L-cells and pancreatic β-cells that release the hormones, peptide YY (PYY) and glucagonlike peptide 1, and insulin, respectively. Endogenous oleoylethanolamide (OEA) and the dietary metabolite, 2-monoacyl...

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Detalles Bibliográficos
Autores principales: Tough, Iain R, Forbes, Sarah, Herzog, Herbert, Jones, Robert M, Schwartz, Thue W, Cox, Helen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972582/
https://www.ncbi.nlm.nih.gov/pubmed/29471473
http://dx.doi.org/10.1210/en.2017-03172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972582/
https://www.ncbi.nlm.nih.gov/pubmed/29471473
http://dx.doi.org/10.1210/en.2017-03172

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