Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells

Interphase phosphorylation of lamin-A,C depends dynamically on a cell's microenvironment, including the stiffness of extracellular matrix. However, phosphorylation dynamics is poorly understood for diseased forms such as progerin, a permanently farnesylated mutant of LMNA that accelerates aging...

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Detalles Bibliográficos
Autores principales: Cho, Sangkyun, Abbas, Amal, Irianto, Jerome, Ivanovska, Irena L., Xia, Yuntao, Tewari, Manu, Discher, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973135/
https://www.ncbi.nlm.nih.gov/pubmed/29619860
http://dx.doi.org/10.1080/19491034.2018.1460185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973135/
https://www.ncbi.nlm.nih.gov/pubmed/29619860
http://dx.doi.org/10.1080/19491034.2018.1460185

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