Synthesis and evaluation of ortho-[(18)F] fluorocelecoxib for COX-2 cholangiocarcinoma imaging

BACKGROUND: An (18)F-tagged NSAID analog was prepared for use as a probe for COX-2 expression, which is associated with tumor development. METHODS: The in vivo uptake of celecoxib was monitored with ortho-[(18)F]fluorocelecoxib using positron emission tomography (PET). The binding affinity of ortho-...

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Detalles Bibliográficos
Autores principales: Chang, Chi-Wei, Yeh, Chun-Nan, Chung, Yi-Hsiu, Chen, Yong-Ren, Tien, Shi-Wei, Chen, Tsung-Wen, Farn, Shiou-Shiow, Huang, Ying-Cheng, Yu, Chung-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973465/
https://www.ncbi.nlm.nih.gov/pubmed/29872269
http://dx.doi.org/10.2147/DDDT.S161718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973465/
https://www.ncbi.nlm.nih.gov/pubmed/29872269
http://dx.doi.org/10.2147/DDDT.S161718

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