Influence of disulfide bond isoforms on drug conjugation sites in cysteine-linked IgG2 antibody-drug conjugates

Cysteine-linked antibody-drug conjugates (ADCs) produced from IgG2 monoclonal antibodies (mAbs) are more heterogeneous than ADCs generated from IgG1 mAbs, as IgG2 ADCs are composed of a wider distribution of molecules, typically containing 0 – 12 drug-linkers per antibody. The three disulfide isofor...

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Detalles Bibliográficos
Autores principales: Liu-Shin, Lily, Fung, Adam, Malhotra, Arun, Ratnaswamy, Gayathri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973704/
https://www.ncbi.nlm.nih.gov/pubmed/29436897
http://dx.doi.org/10.1080/19420862.2018.1440165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973704/
https://www.ncbi.nlm.nih.gov/pubmed/29436897
http://dx.doi.org/10.1080/19420862.2018.1440165

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