Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented into lactate rather than oxidized in mitochondria. However, the signaling events that initiate aerobic glycolysis in T cells remain unclear....

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Detalles Bibliográficos
Autores principales: Menk, Ashley V., Scharping, Nicole E., Moreci, Rebecca S., Zeng, Xue, Guy, Cliff, Salvatore, Sonia, Bae, Heekyong, Xie, Jianxin, Young, Howard A., Wendell, Stacy Gelhaus, Delgoffe, Greg M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973810/
https://www.ncbi.nlm.nih.gov/pubmed/29425506
http://dx.doi.org/10.1016/j.celrep.2018.01.040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973810/
https://www.ncbi.nlm.nih.gov/pubmed/29425506
http://dx.doi.org/10.1016/j.celrep.2018.01.040

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