MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease with poor prognostic implications. This is partly due to a large proportion of PDACs carrying mutations in TP53, which impart gain-of-function characteristics that promote metastasis. There is evidence that microRNAs (miRNAs)...

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Detalles Bibliográficos
Autores principales: Godfrey, Jack D., Morton, Jennifer P., Wilczynska, Ania, Sansom, Owen J., Bushell, Martin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973943/
https://www.ncbi.nlm.nih.gov/pubmed/29844410
http://dx.doi.org/10.1038/s41419-018-0628-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973943/
https://www.ncbi.nlm.nih.gov/pubmed/29844410
http://dx.doi.org/10.1038/s41419-018-0628-4

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