Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice

Activation of TLR2 or TLR4 by endogenous ligands such as high mobility group box 1 (HMGB1) may mediate inflammation causing diabetic kidney injury. We determined whether blockade of HMGB1 signaling by: (1) supra-physiological production of endogenous secretory Receptor for Advanced Glycation End-pro...

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Detalles Bibliográficos
Autores principales: Chen, Xiaochen, Ma, Jin, Kwan, Tony, Stribos, Elisabeth G. D., Messchendorp, A. Lianne, Loh, Yik W., Wang, Xiaoyu, Paul, Moumita, Cunningham, Eithne C., Habib, Miriam, Alexander, Ian E., Sharland, Alexandra F., Chadban, Steven J., Wu, Huiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974129/
https://www.ncbi.nlm.nih.gov/pubmed/29844451
http://dx.doi.org/10.1038/s41598-018-26637-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974129/
https://www.ncbi.nlm.nih.gov/pubmed/29844451
http://dx.doi.org/10.1038/s41598-018-26637-5

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