The effect of N-acetyl-l-cysteine (NAC) on liver toxicity and clinical outcome after hematopoietic stem cell transplantation

Busulphan (Bu) is a myeloablative drug used for conditioning prior to hematopoietic stem cell transplantation. Bu is predominantly metabolized through glutathione conjugation, a reaction that consumes the hepatic glutathione. N-acetyl-l-cysteine (NAC) is a glutathione precursor used in the treatment...

Descripción completa

Detalles Bibliográficos
Autores principales: El-Serafi, Ibrahim, Remberger, Mats, El-Serafi, Ahmed, Benkessou, Fadwa, Zheng, Wenyi, Martell, Eva, Ljungman, Per, Mattsson, Jonas, Hassan, Moustapha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974141/
https://www.ncbi.nlm.nih.gov/pubmed/29844459
http://dx.doi.org/10.1038/s41598-018-26033-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974141/
https://www.ncbi.nlm.nih.gov/pubmed/29844459
http://dx.doi.org/10.1038/s41598-018-26033-z

Ejemplares similares