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The effect of N-acetyl-l-cysteine (NAC) on liver toxicity and clinical outcome after hematopoietic stem cell transplantation

Busulphan (Bu) is a myeloablative drug used for conditioning prior to hematopoietic stem cell transplantation. Bu is predominantly metabolized through glutathione conjugation, a reaction that consumes the hepatic glutathione. N-acetyl-l-cysteine (NAC) is a glutathione precursor used in the treatment...

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Detalles Bibliográficos
Autores principales:	El-Serafi, Ibrahim, Remberger, Mats, El-Serafi, Ahmed, Benkessou, Fadwa, Zheng, Wenyi, Martell, Eva, Ljungman, Per, Mattsson, Jonas, Hassan, Moustapha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974141/ https://www.ncbi.nlm.nih.gov/pubmed/29844459 http://dx.doi.org/10.1038/s41598-018-26033-z

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