Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition

Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2 (PKM2) as its key regulator. Curcumin is an extensively-studied anti-cancer compound, however, its role in affecting cancer metabolism remains poorly understood. Herein, we show that curcumin inhibits glucose uptake and l...

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Detalles Bibliográficos
Autores principales: Siddiqui, Farid Ahmad, Prakasam, Gopinath, Chattopadhyay, Shilpi, Rehman, Asad Ur, Padder, Rayees Ahmad, Ansari, Mohammad Afaque, Irshad, Rasha, Mangalhara, Kailash, Bamezai, Rameshwar N. K., Husain, Mohammad, Ali, Syed Mansoor, Iqbal, Mohammad Askandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974195/
https://www.ncbi.nlm.nih.gov/pubmed/29844464
http://dx.doi.org/10.1038/s41598-018-25524-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974195/
https://www.ncbi.nlm.nih.gov/pubmed/29844464
http://dx.doi.org/10.1038/s41598-018-25524-3

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