Cargando…

Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition

Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2 (PKM2) as its key regulator. Curcumin is an extensively-studied anti-cancer compound, however, its role in affecting cancer metabolism remains poorly understood. Herein, we show that curcumin inhibits glucose uptake and l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siddiqui, Farid Ahmad, Prakasam, Gopinath, Chattopadhyay, Shilpi, Rehman, Asad Ur, Padder, Rayees Ahmad, Ansari, Mohammad Afaque, Irshad, Rasha, Mangalhara, Kailash, Bamezai, Rameshwar N. K., Husain, Mohammad, Ali, Syed Mansoor, Iqbal, Mohammad Askandar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974195/ https://www.ncbi.nlm.nih.gov/pubmed/29844464 http://dx.doi.org/10.1038/s41598-018-25524-3

Ejemplares similares

Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer
por: Prakasam, Gopinath, et al.
Publicado: (2018)

Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2
por: Iqbal, Mohd Askandar, et al.
Publicado: (2013)

Resveratrol Inhibits Cancer Cell Metabolism by Down Regulating Pyruvate Kinase M2 via Inhibition of Mammalian Target of Rapamycin
por: Iqbal, Mohd Askandar, et al.
Publicado: (2012)

DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology
por: Saini, Sunil Kumar, et al.
Publicado: (2017)

DRP1 Promotes BRAF(V600E)-Driven Tumor Progression and Metabolic Reprogramming in Colorectal Cancer
por: Padder, Rayees Ahmad, et al.
Publicado: (2021)

In Silico Screening, Genotyping, Molecular Dynamics Simulation and Activity Studies of SNPs in Pyruvate Kinase M2
por: Kalaiarasan, Ponnusamy, et al.
Publicado: (2015)

The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina
por: Rajala, Raju V. S., et al.
Publicado: (2016)

LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2
por: Lu, Jian, et al.
Publicado: (2018)

MiR-101 Induces Senescence and Prevents Apoptosis in the Background of DNA Damage in MCF7 Cells
por: Manvati, Siddharth, et al.
Publicado: (2014)

Suppressed “Warburg Effect” in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway
por: Zhao, Penglong, et al.
Publicado: (2020)

Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect
por: Li, Zhen, et al.
Publicado: (2021)

Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions
por: Bi, Yang-Hui, et al.
Publicado: (2019)

miR-145 supports cancer cell survival and shows association with DDR genes, methylation pattern, and epithelial to mesenchymal transition
por: Manvati, Siddharth, et al.
Publicado: (2019)

Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase
por: Luo, Fangxiu, et al.
Publicado: (2019)

Enzymatic Activation of Pyruvate Kinase Increases Cytosolic Oxaloacetate to Inhibit the Warburg Effect
por: Wiese, Elizabeth K., et al.
Publicado: (2021)

Implication of BRCA2 -26G>A 5' untranslated region polymorphism in susceptibility to sporadic breast cancer and its modulation by p53 codon 72 Arg>Pro polymorphism
por: Gochhait, Sailesh, et al.
Publicado: (2007)

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
por: Saunier, Elise, et al.
Publicado: (2017)

mTORC2 dictates Warburg effect and drug resistance
por: Masui, Kenta, et al.
Publicado: (2014)

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis
por: Zhan, Cheng, et al.
Publicado: (2015)

The mitochondrial pyruvate carrier as a mediator of the Warburg Effect and its impact on cancer growth and metabolism
por: Schell, John, et al.
Publicado: (2014)

miR-24-2 controls H2AFX expression regardless of gene copy number alteration and induces apoptosis by targeting antiapoptotic gene BCL-2: a potential for therapeutic intervention
por: Srivastava, Niloo, et al.
Publicado: (2011)

TLRs in pulmonary diseases
por: Arora, Shweta, et al.
Publicado: (2019)

Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation
por: Jin, Yue, et al.
Publicado: (2016)

Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex
por: Zhang, Liang, et al.
Publicado: (2021)

Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancer
por: Iqbal, Mohammad Askandar, et al.
Publicado: (2021)

Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome
por: Mohammad, Goran Hamid, et al.
Publicado: (2016)

The Bifunctional Pyruvate Decarboxylase/Pyruvate Ferredoxin Oxidoreductase from Thermococcus guaymasensis
por: Eram, Mohammad S., et al.
Publicado: (2014)

Glutamine metabolism and radiosensitivity: Beyond the Warburg effect
por: Alden, Ryan S., et al.
Publicado: (2022)

Parkin Regulates the Activity of Pyruvate Kinase M2
por: Liu, Kun, et al.
Publicado: (2016)

BRCA1 overexpression attenuates breast cancer cell growth and migration by regulating the pyruvate kinase M2-mediated Warburg effect via the PI3K/AKT signaling pathway
por: Liu, Xiuli, et al.
Publicado: (2022)

Elevated expression of RUNX3 co-expressing with EZH2 in esophageal cancer patients from India
por: Rehman, Asad Ur, et al.
Publicado: (2020)

MUC1-C Oncoprotein Regulates Glycolysis and Pyruvate Kinase m2 Activity in Cancer Cells
por: Kosugi, Michio, et al.
Publicado: (2011)

Expression of tumor pyruvate kinase M2 isoform in plasma and stool of patients with colorectal cancer or adenomatous polyps
por: Rigi, Farideh, et al.
Publicado: (2020)

Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas
por: Li, Yaqing, et al.
Publicado: (2016)

Integrated network pharmacology and experimental analysis unveil multi-targeted effect of 18α- glycyrrhetinic acid against non-small cell lung cancer
por: Irshad, Rasha, et al.
Publicado: (2022)

Obsessive Compulsive Disorder Presenting as Neurological Emergency
por: Dar, Mansoor Ahmad, et al.
Publicado: (2015)

Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia
por: Aloysius, Mark M, et al.
Publicado: (2009)

Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer
por: Mohammad, Goran Hamid, et al.
Publicado: (2019)

Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency
por: Rodrigues, Ana Sofia, et al.
Publicado: (2015)

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis
por: Zhou, Haiping, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_88m7gpjdfh8b3icbtah6hi2tka