The cyclohexene derivative MC-3129 exhibits antileukemic activity via RhoA/ROCK1/PTEN/PI3K/Akt pathway-mediated mitochondrial translocation of cofilin

The effects of MC-3129, a synthetic cyclohexene derivative, on cell viability and apoptosis have been investigated in human leukemia cells. Exposure of leukemia cells to MC-3129 led to the inhibition of cell viability and induction of apoptosis through the dephosphorylation and mitochondrial translo...

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Detalles Bibliográficos
Autores principales: Zheng, Yi, Ouyang, Qin, Fu, Ruoqiu, Liu, Lei, Zhang, Hongwei, Hu, Xiaoye, Liu, Yanxia, Chen, Yingchun, Gao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974298/
https://www.ncbi.nlm.nih.gov/pubmed/29844397
http://dx.doi.org/10.1038/s41419-018-0689-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974298/
https://www.ncbi.nlm.nih.gov/pubmed/29844397
http://dx.doi.org/10.1038/s41419-018-0689-4

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