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Oleuropein aglycone stabilizes the monomeric α-synuclein and favours the growth of non-toxic aggregates
α-synuclein plays a key role in the pathogenesis of Parkinson’s disease (PD); its deposits are found as amyloid fibrils in Lewy bodies and Lewy neurites, the histopathological hallmarks of PD. Amyloid fibrillation is a progressive polymerization path starting from peptide/protein misfolding and proc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974307/ https://www.ncbi.nlm.nih.gov/pubmed/29844450 http://dx.doi.org/10.1038/s41598-018-26645-5 |