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Niche-induced extramedullary hematopoiesis in the spleen is regulated by the transcription factor Tlx1

Extramedullary hematopoiesis (EMH) in postnatal life is a pathological process in which the differentiation of hematopoietic stem/progenitor cells (HSPCs) occurs outside the bone marrow (BM) to respond to hematopoietic emergencies. The spleen is a major site for EMH; however, the cellular and molecu...

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Detalles Bibliográficos
Autores principales: Oda, Akihisa, Tezuka, Toshiki, Ueno, Yuta, Hosoda, Shoko, Amemiya, Yusuke, Notsu, Chihiro, Kasahara, Toru, Nishiyama, Chiharu, Goitsuka, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974313/
https://www.ncbi.nlm.nih.gov/pubmed/29844356
http://dx.doi.org/10.1038/s41598-018-26693-x