Cargando…
SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and differentiation through repression of MYF5 and MYOD function
Rhabdomyosarcoma (RMS) is a mesenchymal tumor of soft tissue in children that originates from a myogenic differentiation defect. Expression of SNAIL transcription factor is elevated in the alveolar subtype of RMS (ARMS), characterized by a low myogenic differentiation status and high aggressiveness....
Autores principales: | Skrzypek, Klaudia, Kusienicka, Anna, Trzyna, Elzbieta, Szewczyk, Barbara, Ulman, Aleksandra, Konieczny, Pawel, Adamus, Tomasz, Badyra, Bogna, Kortylewski, Marcin, Majka, Marcin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974324/ https://www.ncbi.nlm.nih.gov/pubmed/29844345 http://dx.doi.org/10.1038/s41419-018-0693-8 |
Ejemplares similares
-
Progression and Differentiation of Alveolar Rhabdomyosarcoma Is Regulated by PAX7 Transcription Factor—Significance of Tumor Subclones
por: Skrzypek, Klaudia, et al.
Publicado: (2021) -
Enhancement of myogenic differentiation and inhibition of rhabdomyosarcoma progression by miR-28-3p and miR-193a-5p regulated by SNAIL
por: Skrzypek, Klaudia, et al.
Publicado: (2021) -
Constitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression
por: Skrzypek, Klaudia, et al.
Publicado: (2015) -
SNAIL Promotes Metastatic Behavior of Rhabdomyosarcoma by Increasing EZRIN and AKT Expression and Regulating MicroRNA Networks
por: Skrzypek, Klaudia, et al.
Publicado: (2020) -
Genome Editing of the SNAI1 Gene in Rhabdomyosarcoma: A Novel Model for Studies of Its Role
por: Ulman, Aleksandra, et al.
Publicado: (2020)