Kcne4 deletion sex-specifically predisposes to cardiac arrhythmia via testosterone-dependent impairment of RISK/SAFE pathway induction in aged mice

Sudden cardiac death (SCD) is associated with both electrical and ischemic substrates, and is a major cause of ischemic heart disease mortality worldwide. Male sex predisposes to SCD but the underlying mechanisms are incompletely understood. KCNE4, a cardiac arrhythmia-associated potassium channel β...

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Detalles Bibliográficos
Autores principales: Hu, Zhaoyang, Wei, Wei, Zhou, Leng, Chen, Mou, Abbott, Geoffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974354/
https://www.ncbi.nlm.nih.gov/pubmed/29844497
http://dx.doi.org/10.1038/s41598-018-26599-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974354/
https://www.ncbi.nlm.nih.gov/pubmed/29844497
http://dx.doi.org/10.1038/s41598-018-26599-8

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