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The relative resistance of children to sepsis mortality: from pathways to drug candidates

Attempts to develop drugs that address sepsis based on leads developed in animal models have failed. We sought to identify leads based on human data by exploiting a natural experiment: the relative resistance of children to mortality from severe infections and sepsis. Using public datasets, we ident...

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Detalles Bibliográficos
Autores principales: Joachim, Rose B, Altschuler, Gabriel M, Hutchinson, John N, Wong, Hector R, Hide, Winston A, Kobzik, Lester
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974511/
https://www.ncbi.nlm.nih.gov/pubmed/29773677
http://dx.doi.org/10.15252/msb.20177998