Cargando…

Oxymatrine Causes Hepatotoxicity by Promoting the Phosphorylation of JNK and Induction of Endoplasmic Reticulum Stress Mediated by ROS in LO2 Cells

Oxymatrine (OMT) often used in treatment for chronic hepatitis B virus infection in clinic. However, OMT–induced liver injury has been reported. In this study, we aim to investigate the possible mechanism of OMT-induced hepatotoxicity in human normal liver cells (L02). Exposed cells to OMT, the cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Li-li, Shen, Zhe-lun, Li, Yang-Lei, Bao, Yi-Qi, Lu, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974617/ https://www.ncbi.nlm.nih.gov/pubmed/29754474 http://dx.doi.org/10.14348/molcells.2018.2180

Ejemplares similares

Oxymatrine attenuates arsenic-induced endoplasmic reticulum stress and calcium dyshomeostasis in hepatic stellate cells
por: Wang, Huiqun, et al.
Publicado: (2020)

Mechanism of Oxymatrine-induced Human Esophageal Cancer Cell Apoptosis by the Endoplasmic Reticulum Stress Pathway
por: Wang, Baiyan, et al.
Publicado: (2018)

The Increase of ROS Caused by the Interference of DEHP with JNK/p38/p53 Pathway as the Reason for Hepatotoxicity
por: Huang, Yuanyuan, et al.
Publicado: (2019)

The Role of Oxymatrine in Amelioration of Acute Lung Injury Subjected to Myocardial I/R by Inhibiting Endoplasmic Reticulum Stress in Diabetic Rats
por: Huang, Yongpan, et al.
Publicado: (2020)

Oxymatrine and its metabolite matrine contribute to the hepatotoxicity induced by radix Sophorae tonkinensis in mice
por: Gu, Yingmin, et al.
Publicado: (2019)

Endoplasmic Reticulum Stress and Associated ROS
por: Zeeshan, Hafiz Maher Ali, et al.
Publicado: (2016)

Oxymatrine exerts anti-fibrotic effects in a rat model of hepatic fibrosis by suppressing endoplasmic reticulum stress
por: Liu, Xiaodong, et al.
Publicado: (2020)

Endoplasmic Reticulum Stress and Autophagy Are Involved in Hepatotoxicity Induced by Tributyltin
por: Liang, Weiqi, et al.
Publicado: (2023)

ROS and Endoplasmic Reticulum Stress in Pulmonary Disease
por: Cui, Xiangning, et al.
Publicado: (2022)

Effect of oxymatrine on liver gluconeogenesis is associated with the regulation of PEPCK and G6Pase expression and AKT phosphorylation
por: Zhu, Yu-Xian, et al.
Publicado: (2021)

γ-Glutamylcysteine Alleviates Ischemic Stroke-Induced Neuronal Apoptosis by Inhibiting ROS-Mediated Endoplasmic Reticulum Stress
por: Li, Hui-qin, et al.
Publicado: (2021)

Disruption of Endoplasmic Reticulum and ROS Production in Human Ovarian Cancer by Campesterol
por: Bae, Hyocheol, et al.
Publicado: (2021)

Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythematosus
por: Guo, Genkai, et al.
Publicado: (2015)

Citrinin-Induced Hepatotoxicity in Mice Is Regulated by the Ca(2+)/Endoplasmic Reticulum Stress Signaling Pathway
por: Wu, Dongyi, et al.
Publicado: (2022)

Miltirone exhibits antileukemic activity by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction pathways
por: Zhou, Ling, et al.
Publicado: (2016)

Seawater inhalation induces acute lung injury via ROS generation and the endoplasmic reticulum stress pathway
por: Li, Peng-Cheng, et al.
Publicado: (2018)

Zearalenone Induces Apoptosis in Porcine Endometrial Stromal Cells through JNK Signaling Pathway Based on Endoplasmic Reticulum Stress
por: Zhao, Jie, et al.
Publicado: (2022)

Targeted Induction of Endoplasmic Reticulum Stress Induces Cartilage Pathology
por: Rajpar, M. Helen, et al.
Publicado: (2009)

Elaidic acid induces cell apoptosis through induction of ROS accumulation and endoplasmic reticulum stress in SH-SY5Y cells
por: Ma, Wei-Wei, et al.
Publicado: (2017)

The Reciprocal Causation of the ASK1-JNK1/2 Pathway and Endoplasmic Reticulum Stress in Diabetes-Induced Cognitive Decline
por: Wu, Yanqing, et al.
Publicado: (2020)

Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy
por: Liu, Zhong-Wei, et al.
Publicado: (2013)

Oxymatrine attenuates lipopolysaccharide-induced acute lung injury by activating the epithelial sodium channel and suppressing the JNK signaling pathway
por: Jin, Bingji, et al.
Publicado: (2018)

Induction of Apurinic Endonuclease 1 Overexpression by Endoplasmic Reticulum Stress in Hepatoma Cells
por: Cheng, Tsung-Lin, et al.
Publicado: (2014)

Selective inhibition of JNK located on mitochondria protects against mitochondrial dysfunction and cell death caused by endoplasmic reticulum stress in mice with LPS-induced ALI/ARDS
por: Li, Congcong, et al.
Publicado: (2022)

EGFR inhibition attenuates diabetic nephropathy through decreasing ROS and endoplasmic reticulum stress
por: Xu, Zheng, et al.
Publicado: (2017)

Ferroptosis and endoplasmic reticulum stress in ischemic stroke
por: Li, Yina, et al.
Publicado: (2023)

Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response()
por: Haberzettl, Petra, et al.
Publicado: (2013)

THE ENDOPLASMIC RETICULUM
por: Palade, George E.
Publicado: (1956)

Corrigendum: The Reciprocal Causation of the ASK1-JNK1/2 Pathway and Endoplasmic Reticulum Stress in Diabetes-Induced Cognitive Decline
por: Wu, Yanqing, et al.
Publicado: (2021)

The Tricalbin-Family Endoplasmic Reticulum-Plasma Membrane Tethering Proteins Attenuate ROS-Involved Caspofungin Sensitivity in Candida albicans
por: Yang, Li, et al.
Publicado: (2022)

Structural reorganization of the fungal endoplasmic reticulum upon induction of mycotoxin biosynthesis
por: Boenisch, Marike Johanne, et al.
Publicado: (2017)

Endoplasmic Reticulum Stress-Induced JNK Activation Is a Critical Event Leading to Mitochondria-Mediated Cell Death Caused by β-Lapachone Treatment
por: Lee, Hyemi, et al.
Publicado: (2011)

Mechanism and Role of Endoplasmic Reticulum Stress in Osteosarcoma
por: Zhu, Peijun, et al.
Publicado: (2022)

Oxymatrine Attenuates Osteoclastogenesis via Modulation of ROS-Mediated SREBP2 Signaling and Counteracts Ovariectomy-Induced Osteoporosis
por: Jiang, Chao, et al.
Publicado: (2021)

Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma
por: Li, Zichao, et al.
Publicado: (2019)

Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells
por: Cheng, Xiu, et al.
Publicado: (2021)

Intracellular Sources of ROS/H(2)O(2) in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum
por: Konno, Tasuku, et al.
Publicado: (2021)

ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress
por: Wan, Xiao-shan, et al.
Publicado: (2014)

HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress‐driven hepatocellular carcinoma progression
por: He, Lin, et al.
Publicado: (2023)

Corrigendum to “ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress”
por: Wan, Xiao-shan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_d6737jt3o10i7dac1tvpgkd6th