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Hypoxic‐induction of arginase II requires EGF‐mediated EGFR activation in human pulmonary microvascular endothelial cells

We have previously shown that hypoxia‐induced proliferation of human pulmonary microvascular endothelial cells (hPMVEC) depends on arginase II, and that epidermal growth factor receptor (EGFR) is necessary for hypoxic‐induction of arginase II. However, it remains unclear how hypoxia activates EGFR‐m...

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Detalles Bibliográficos
Autores principales: Pool, Caitlyn M., Jin, Yi, Chen, Bernadette, Liu, Yusen, Nelin, Leif D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974731/
https://www.ncbi.nlm.nih.gov/pubmed/29845760
http://dx.doi.org/10.14814/phy2.13693