Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

High failure rates of drug candidates in the clinics, restricted-use warnings as well as withdrawals of drugs in postmarketing stages are of substantial concern for the pharmaceutical industry and drug-induced liver injury (DILI) constitutes one of the most frequent reasons for such safety failures....

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Detalles Bibliográficos
Autores principales: Vorrink, Sabine U, Zhou, Yitian, Ingelman-Sundberg, Magnus, Lauschke, Volker M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
3d Hepatic Spheroid Cultures for Predicting Toxicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974779/
https://www.ncbi.nlm.nih.gov/pubmed/29590495
http://dx.doi.org/10.1093/toxsci/kfy058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974779/
https://www.ncbi.nlm.nih.gov/pubmed/29590495
http://dx.doi.org/10.1093/toxsci/kfy058

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