Differences Between Lovastatin and Simvastatin Hydrolysis in Healthy Male and Female Volunteers: Gut Hydrolysis of Lovastatin is Twice that of Simvastatin

The aim of this pharmacokinetic evaluation was to show the effect of the extra methyl group in simvastatin on esterase hydrolysis between lovastatin and simvastatin in male and female volunteers. This study was based on the plasma concentration-time curves and the pharmacokinetics of lovastatin and...

Descripción completa

Detalles Bibliográficos
Autores principales: Vree, Tom B., Dammers, Erik, Ulc, Ivan, Horkovics-Kovats, Stefan, Ryska, Miroslav, Merkx, IJsbrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974895/
https://www.ncbi.nlm.nih.gov/pubmed/14755114
http://dx.doi.org/10.1100/tsw.2003.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974895/
https://www.ncbi.nlm.nih.gov/pubmed/14755114
http://dx.doi.org/10.1100/tsw.2003.121

Ejemplares similares