MMP‐13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation

ESSENTIALS: MMP‐13 has the potential to influence platelet function and thrombus formation directly. We sought to elucidate whether MMP‐13 is able to bind to specific platelet receptors. MMP‐13 is able to bind to platelet alphaIIbbeta3 (αIIbβ3) and glycoprotein (GP)VI. These interactions are suffici...

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Detalles Bibliográficos
Autores principales: Howes, Joanna‐Marie, Pugh, Nicholas, Hamaia, Samir W., Jung, Stephanie M., Knäuper, Vera, Malcor, Jean‐Daniel, Farndale, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles: Haemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974921/
https://www.ncbi.nlm.nih.gov/pubmed/30046741
http://dx.doi.org/10.1002/rth2.12088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974921/
https://www.ncbi.nlm.nih.gov/pubmed/30046741
http://dx.doi.org/10.1002/rth2.12088

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