Effect of sample size re-estimation in adaptive clinical trials for Alzheimer's disease and mild cognitive impairment

INTRODUCTION: The sample size re-estimation (SSR) adaptive design allows interim analyses and resultant modifications of the ongoing trial to preserve or increase power. We investigated the applicability of SSR in Alzheimer's disease (AD) trials using a meta-database of clinical studies. METHOD...

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Detalles Bibliográficos
Autores principales: Wang, Guoqiao, Kennedy, Richard E., Cutter, Gary R., Schneider, Lon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975045/
https://www.ncbi.nlm.nih.gov/pubmed/29854926
http://dx.doi.org/10.1016/j.trci.2015.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975045/
https://www.ncbi.nlm.nih.gov/pubmed/29854926
http://dx.doi.org/10.1016/j.trci.2015.03.002

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