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Crucial role of chelatable iron in silver nanoparticles induced DNA damage and cytotoxicity

Damage to mitochondria and subsequent ROS leakage is a commonly accepted mechanism of nanoparticle toxicity. However, malfunction of mitochondria results in generation of superoxide anion radical (O(2)(•)-), which due to the relatively low chemical reactivity is rather unlikely to cause harmful effe...

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Detalles Bibliográficos
Autores principales: Grzelak, Agnieszka, Wojewódzka, Maria, Meczynska-Wielgosz, Sylwia, Zuberek, Mariusz, Wojciechowska, Dominika, Kruszewski, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975067/
https://www.ncbi.nlm.nih.gov/pubmed/29351884
http://dx.doi.org/10.1016/j.redox.2018.01.006